PURPOSE: A drink composition for hangover cure is provided to immediately and continuously reduce the hangover effect. CONSTITUTION: Drink composition for hangover cure comprises 100 parts by weight of red ginseng extract concentrate and 400~600 parts by weight of fruit mixing concentrate. Drink composition for hangover cure additionally comprises natural plant concentrate which concentrates Chinese matrimony vine, persimmon leaf, lycium root, dried orange peel, hovenia dulcis fruit and Artemisia capillaris. Fruit mixing concentrate is manufactured as follows. 10~20 parts by weight of ginger is extracted with water. 100 parts by weight of pear, 60~80 parts by weight of apple, 40~50 parts by weight of quince, 30~50 parts by weight citron, and 10~20 parts by weight of mango are put into ginger extraction liquid to be extracted. Extract is concentrated. Natural plant concentrate is extracted from the mixture of 50~70 parts by weight of persimmon leaf, 30~45 parts by weight of lycium root, 25~40 parts by weight of dried orange peel, 10~15 parts by weight of hovenia dulcis fruit, and 3~5 parts by weight of Artemisia capillaris to 100 parts by weight of Chinese matrimony vine. Extracts are mixed and fermented. [Reference numerals] (AA) Comparison example; (BB) Example 1; (CC) Example 2; (DD) Example 3; (EE) Comparison example 1; (FF) Comparison example 2; (GG) Comparison example 3; (HH) Minutes본 발명은 알콜의 흡수를 저해하는 한편 대사를 촉진시켜 음주 직후의 체내 알콜 농도를 저하시킬 뿐 아니라 알콜 분해 및 숙취 해소 효과가 우수한 숙취 해소용 음료 조성물에 관한 것으로, 보다 상세하게는 홍삼의 알코올 추출물을 농축한 홍삼농축액; 배, 사과, 모과, 유자 및 망고의 물 추출물을 농축한 과일혼합농축액;을 함유하는 것을 특징으로 하는 숙취해소용 음료 조성물에 관한 것이다.