The present invention relates to an antibody having an anti-angiogenesis activity. More specifically, the present invention relates to an antibody against ROBO4 and a pharmaceutical composition containing the antibody.An object of the present invention is to provide an anti-ROBO4 antibody having an anti-angiogenesis effect, a pharmaceutical composition or the like comprising the antibody, a method for suppressing angiogenesis using the antibody, etc. Another object of the present invention is to provide a method for producing the antibody.The antibody of the present invention activates the downstream signal of ROBO4 and has a suppressive activity against cell migration induced by VEGF or bFGF. The antibody of the present invention also exhibits an anti-angiogenesis effect in in-vivo models. Thus, the problem has been solved.本發明係關於具有抗血管生成活性之抗體。更具體而言,本發明係關於針對ROBO4之抗體及含有該抗體之醫藥組合物。本發明之一個目標係提供具有抗血管生成效應之抗ROBO4抗體、包含該抗體之醫藥組合物或諸如此類、使用該抗體阻抑血管生成之方法等。本發明之另一目標係提供產生該抗體之方法。本發明抗體活化ROBO4之下游信號且具有針對VEGF或bFGF所誘導細胞移行之阻抑活性。本發明抗體在活體內模型中亦展現抗血管生成效應。因此,該問題已解決。
