/ 2 ORAL FORMULATIONS MIMETIC OF ROUX-EN-Y GASTRIC BYPASS ACTIONS ON THE ILEAL BRAKE/ COMPOSITIONS METHODS OF TREATMENT DIAGNOSTICS AND SYSTEMS FOR TREATMENT OF METABOLIC SYNDROME MANIFESTATIONS INCLUDING INSULIN RESISTANCE FATTY LIVER DISEASE HYPERLIPIDEMIA AND T2D
The present invention relates to the treatment of various metabolic syndromes including hyperlipidemia, weight gain, obesity, insulin resistance, hypertension, atherosclerosis, fatty liver diseases and certain chronic inflammatory diseases, pharmaceutical compositions, methods for treatment, and related diagnostics And computer-implementable systems. In an additional aspect of the present invention, the therapeutic compositions and methods are corrected for surgical surgery, eg, ileal braking response to RYGB, all because they act in the gastrointestinal tract or liver of a mammal to control the signs of metabolic syndrome. Activating braking, thereby reversing or ameliorating cardiovascular damage (atherosclerosis, hypertension, lipid accumulation, etc.) resulting from the progression of metabolic syndrome, with the advantage of including glucose as the active agent for ileal braking. , With one medicament, is the possibility of treating all common signs of metabolic syndrome, including type 2 diabetes and obesity. The ileal braking is a controller for the progression of metabolic syndrome, and both RYGB surgery and oral formulations work beneficially on metabolic syndrome signs via this pathway. Combination drugs are also disclosed that act synergistically with ileal braking and signs of metabolic syndrome. In other aspects, the present invention provides selective control of appetite, stabilization of blood sugar and insulin levels, and treatment of gastrointestinal disorders in a manner similar to RYGB surgery, with at least 20% efficacy to stimulate hormonal response of ileal braking in humans. Ileal braking hormone releasing compositions, methods of treatment, diagnostics, and related systems useful in the art.본 발명은 고지혈증, 체중 증가, 비만, 인슐린 저항성, 고혈압, 죽상동맥경화증, 지방간 질환들 및 특정 만성 염증 질환들을 포함하는 다양한 대사 증후군들의 치료에 관한, 약학 조성물, 치료를 위한 방법들, 및 관련 진단과 컴퓨터로 구현가능한 시스템들을 제공한다. 본 발명의 부가적인 양상에서, 치료 조성물과 방법들은 외과 수술, 예를 들면 RYGB에 대한 회장 제동 반응으로 보정되는데, 그 이유는 모두 대사 증후군 징후들을 제어하기 위하여 포유류의 위
