#$%^&*AU2016253697A120161124.pdf#####H:\dar\Intrwoven\NRPortbl\DCC\DAR\11864009_1.DOC-10/31/2016 ABSTRACT The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the 5 invention and methods of using the compositions in the treatment of various diseases.