The present invention relates to compounds of the formula (I) oligosaccharide-spacer-A (1), wherein the oligosaccharide is a negatively charged oligosaccharide residue comprising two to twenty five monosaccharide units, the charge being compensated by positively charged counterions, and wherein the oligosaccharide residue is derived from an oligosaccharide which has (AT-III mediated) anti-Xa activity per se； the spacer is an essentially pharmacologically inactive flexible linking residue having a chain length of 10 to 70 atoms； A is the residue &mdash；CH[NH&mdash；SO2&mdash；R1[CO&mdash；NR2&mdash；CH(4-benzamidine)-CO&mdash；NR3R4], wherein R1 is phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, (iso)quinolinyl, tetrahydro(iso)quinolinyl, 3,4-dihydro-1H-isoquinolinyl, chromanyl or the camphor group, which groups may optionally be substituted with one or more substituents selected from (1-8C)alkyl or (1-8C)alkoxy； and wherein R2 and R3 are independently H or (1-8C)alkyl； R4 is (-8C)alkyl or (3-8C)cycloalkyl； or R3 and R4 together with the nitrogen atom to which they are bonded are a nonaromatic (4-8) membered ring optionally containing another heteroatom, the ring optionally being substituted with (1-8C)alkyl or SO2-(1-8C)alkyl； or a pharmaceutically acceptable salt thereof a prodrug or solvate thereof； wherein the compound of formula I further comprises at least one covalent bond with a biotin residue or an analogue thereof. The compounds of the invention have antithrombotic activity and can be used in treating or preventing thrombosis or other thrombin-related diseases. The antithrombotic activity of the compound of this invention can be neutralized in case of emergency upon administration of avidin, streptavidin and analogues thereof having high biotin affinity.본 발명은 하기 화학식 I의 화합물, 또는 이의 약학적 허용염 또는 전구 약물 또는 용매화물(여기서, 화학식 I의 화합물은 비오틴 잔기 또는 이의 유사체와의 1 이상의 공유 결합을 더 포함함)에 관한 것이다:화학식 I올리고당-스페이서-A상기 화학식에서, 올리고당은 2 내지 25 개의 단당류 단위를 포함하는, 음으로 하전된 올리고당 잔기이고, 전하는 양으로 하전된 반대 이온에 의해
