Provided are methods for producing compositions comprising a population of cardiomyocytes enriched for or substantially devoid of sinoatrial node-like pacemaker cardiomyocytes (SANLCM) from human pluripotent stem cells (hPSCs), and methods of use thereof.Linvention concerne des procédés de production de compositions comprenant une population de cardiomyocytes enrichie en cardiomyocytes stimulateurs de type sino-auriculaire (SANLCM) ou sensiblement exempte desdits cardiomyocytes, à partir de cellules souches pluripotentes humaines (hPSC), et des procédés dutilisation desdites compositions.