Bifunctional chelating agents based on the 1,4-diazepine scaffold (DAZA) for non-invasive molecular imaging

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专利权人:

JOHANNES GUTENBERG-UNIVERSITÄT MAINZ

发明人:

Frank Rösch,Bradley Peter Waldron,David Parker

申请号：

US14897142

公开号：

US10130722B2

申请日:

2014.05.14

申请国别(地区):

US

年份:

2018

代理人:

摘要：

A compound for radio metal complexation includes a chelator and one or more biological targeting vectors TV conjugated to said chelator, wherein the chelator has structure (A) or (B) or (C),based on 1,4-diazepine with groups R1, R2, R3, R4, X1, X2, X3. The compound is particularly suited for complexation of radio-isotopic metals, such as 66Ga(III), 67Ga(III) and 68Ga(III).

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