Devices, systems, and methods use a catheter device sized and configured forintroduction to a targeted site in a hollow body organ or blood vessel. Thecatheter device includes a first release mechanisms coupled to the prosthesisto secure at least one region of the prosthesis to the catheter shaft, and asecond release mechanism coupled to the prosthesis in cooperation with thefirst release mechanism to prevent full release of the at least one region ofthe at least one region of the prosthesis from the catheter shaft afteractuation of the first release mechanism. A fastening device sized andconfigured- for introduction to the targeted site in the hollow body organ orblood vessel occupied by the catheter device, includes an actuator to deploy afastener in the at least one region of the prosthesis after actuation of thefirst release mechanism and before actuation of the second release mechanism.
