This invention, the human insulin way with growth factor 1 (IGF-1) origin, includes the IGF 1 imitation (mimicking) peptide which includes specification amino acid arrangement, and this, improvement or the tooth of skin state (conditions) lap it regards the composition for remedy of disease. The IGF 1 imitation peptide of this invention does function or the action which is similar to natural person IGF 1, stability is very high by comparison with nature IGF 1, is superior very to skin permeability. Therefore, although the composition which includes the peptide of this invention remedies the disease or a state where IGF 1 activity is required, prevents or improves you can show the effect which is superior very, can apply to the item and the cosmetics outside the medicine and the medicine very profitably< Selective figure >Figure 8本発明は、ヒトインシュリン様成長因子-1(IGF-1)由来で、特定アミノ酸配列を含むIGF-1模倣(mimicking)ペプチド、並びにこれを含む、皮膚状態(conditions)の改善または歯周疾患の治療用組成物に関する。本発明のIGF-1模倣ペプチドは、天然のヒトIGF-1と同様な機能または作用をし、安定性が天然IGF-1と比較して非常に高く、皮膚透過度に非常に優れている。したがって、本発明のペプチドを含む組成物は、IGF-1活性が要求される疾患または状態を治療、予防または改善するのに非常に優れた効能を発揮し、医薬、医薬外品及び化粧品に非常に有利に適用できる【選択図】図8
