INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
发明人:
DIMARCHI RICHARD D.,TAO MA
申请号：
NZ60344509
公开号：
NZ603445A
申请日:
2009.06.16
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
603445 Disclosed is an analog of glucagon having an amino acid sequence of HSQGTFTSDYSKYLDSRRAQDFVQWLMNT and having GIP agonist activity comprising an acyl group, wherein the acyl group is attached to a spacer, wherein: (i) the spacer is attached to the side chain of the amino acid at position 10 of the analog or (ii) the analog comprises an extension of 1 to 21 amino acids C-terminal to the amino acid at position 29 and the spacer is attached to the side chain of an amino acid corresponding to one of positions 37-43 relative to HSQGTFTSDYSKYLDSRRAQDFVQWLMNT wherein the analog exhibits at least 1% activity of native GIP at the GIP receptor.
