LEMIEUX RENE MARC,BRUNETTE STEVEN RICHARD,HORAN JOSHUA COURTNEY,KOWALSKI JENNIFER A.,LAWLOR MICHAEL DAVID,MCKIBBEN BRYAN,MILLER CRAIG ANDREW,BARBOSA ANTONIO J.M.
申请号：
NZ59562210
公开号：
NZ595622A
申请日:
2010.05.26
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
595622 Disclosed herein are derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid amide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease. In one embodiment the derivative is (R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid ((1S,2R)-1-{ 1-[5-(1,3-dimethyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-cyclopropylcarbamoyl} -2-hydroxy-propyl)-amide.
