對CD47和PD-L1特異性的抗體农业专利-农业专业知识服务系统

发明人:: SOLOVYEV, KIRILL VLADIMIROVICH,索洛维耶夫　吉利尔弗拉基米罗维,索洛維耶夫　吉利爾弗拉基米羅維,ULITIN, ANDREI BORISOVICH,乌里京　安德列鲍里索维奇,烏裡京　安德列鮑裡索維奇,NEMANKIN, TIMOFEY ALEKSANDROVICH,聂曼金　蒂莫菲亚历山德罗维,聶曼金　蒂莫菲亞曆山德羅維,SOLOVYEV, VALERY V

摘要：: The present invention relates to the field of bioengineering, specifically to antibodies or their antigen-binding fragments, and to the use thereof. More particularly, the present invention relates to antibodies that bind specifically to CD47 and PD-L1. The invention also relates to a nucleic acid that codes for the given antibody or for the antigen-binding fragment thereof, to an expression vector, to a method of producing the antibody, and to a use of the aforementioned antibodies and compositions in cancer treatment.本發明涉及生物技術，尤其涉及抗體或其抗原結合片段及其用途。更具體而言，本發明涉及與CD47和PD-L1特異性結合的抗體。本發明還涉及編碼所述抗體或其抗原結合片段的核酸，表達載體，所述抗體的製備方法，以及所述抗體與組合物在癌症治療中的用途。