Olhava Edward J.,Chesworth Richard,Pollock Roy M.,Jin Lei
申请号：
US201615176052
公开号：
US10112968(B2)
申请日:
2016.06.07
申请国别(地区):
美国
年份:
2018
代理人:
Cooley LLP `Erlacher Heidi A.`Sun Xixi
摘要：
The present invention relates to DOT1L inhibitors and methods of identifying, designing, or optimizing them. The present invention also relates to crystals of DOT1L-inhibitor complexes, the crystal structures thereof, and the use of the crystal structures. Also disclosed are pharmaceutical compositions containing these DOT1L inhibitors and methods of treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
