DOUGLAS CHARLES HANSON,MARK JOSEPH NEVEU,EILEEN ELLIOT MUELLER,JEFFREY HERBERT HANKE,STEVEN CHRISTOPHER GILMAN,C. GEOFFREY DAVIS,JOSÉ RAMON CORVALAN
申请号：
PT90071614
公开号：
PT2112166T
申请日:
1999.12.23
申请国别(地区):
PT
年份:
2019
代理人:
摘要：
In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.
