AN IMPROVED METHOD FOR HIGH LEVEL PRODUCTION OF CRM197

• 收藏
• 分享

专利权人:

Biological E Limited

发明人:

Balamurali Masilamani,Rajan Sriraman,Mandar Shirish Dixit,Deviprasanna Chakka,Satyam Naidu Sureddi,Ramesh Venkat Matur,Narender Dev Mantena,Mahima Datla

申请号：

US16606958

公开号：

US20200277341A1

申请日:

2018.04.19

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The present invention provides an improved method for the production of CRM197 with high yield using engineered Corynebacterium diphtheria strain having an increased copy number of the CRM197 gene, wherein the method comprises growing the strain in media free of animal-derived components with one or more amino acids.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/