abstract compositions comprising glucopyranosyl lipid adjuvant (gla) and methods for reducing or preventing the formation of cancer metastasis using same are provided. the compositions may be formulated for local-regional delivery. the compositions may be substantially devoid of a cancer antigen. the treatment with gla may be combined with treatment with a cox2 inhibitor and a beta-adrenergic blocker. ---------------- translation of the patent summary summary of invention: "compositions and methods for reducing or preventing metastasis". the present invention relates to compositions comprising glycopyranosyl (gla) lipid adjuvant and methods for reducing or preventing the formation of cancer metastasis using the same are provided. the compositions can be formulated for local-regional application. the compositions can be substantially devoid of a cancer antigen. gla treatment can be combined with treatment with a cox2 inhibitor and a beta-adrenergic blocker.abstract compositions comprising glucopyranosyl lipid adjuvant (gla) and methods for reducing or preventing the formation of cancer metastasis utilizing same are provided. the compositions may be formulated for local-regional delivery. the compositions may be substantially devoid of a cancer antigen. the treatment with gla may be combined with treatment with a cox2 inhibitor and a beta-adrenergic blocker. ---------------- tradução do resumo resumo patente de invenção: "composições e métodos para redução ou prevenção de metástase". a presente invenção refere-se a composições compreen-dendo adjuvante de lipídeo de glicopiranosila (gla) e métodos para redução ou prevenção da formação de metástase de câncer utilizando as mesmas são providos. as composições podem ser formuladas para aplicação local-regional. as composições podem ser substancialmente destituídas de um antígeno para câncer. o tratamento com gla pode ser combinado com tratamento com um inibidor de cox2 e um blo-queador beta-adrenérgico.