Disclosed herein is the use of a compound of formula I or a single stereoisomer or tautomer thereof where the Compound is optionally as a pharmaceutically acceptable salt and additionally optionally as a hydrate and additionally optionally as a solvate thereof for the manufacture of a medicament for administration in combination with one or more treatments independently selected from surgery, one or more chemotherapeutic agents, one or more of the hormone therapies, one or more antibodies, one or more immunotherapies, radioactive iodine therapy, and radiation for treating cancer (such as breast cancer, colon cancer, rectal cancer, endometrial cancer, gastrointestinal carcinoid tumors, gastrointestinal stromal tumors, glioblastoma, hepatocellular carcinoma, small cell lung cancer, non-small cell lung cancer, melanoma, ovarian cancer, cervical cancer, pancreatic cancer, prostate carcinoma, acute myelogenous leukemia, chronic myelogenous leukemia, non-Hodgkins lymphoma, and thyroid carcinoma) in a patient in need thereof, wherein the substituents of the Compound of Formula I are as defined within the specification.
