Macdonald Lynn,McWhirter John,Gurer Cagan,Meagher Karolina A.,Murphy Andrew J.
申请号：
US201313944286
公开号：
US9932398(B2)
申请日:
2013.07.17
申请国别(地区):
美国
年份:
2018
代理人:
Wu Rita S.`Gont Ilona`Goldberg Elysa
摘要：
Mice having a restricted immunoglobulin heavy chain locus are provided, wherein the locus is characterized by a single polymorphic human VH gene segment, a plurality of human DH gene segments and a plurality of JH gene segments. Methods for making antibody sequences that bind an antigen (e.g., a viral antigen) are provided, comprising immunizing a mouse with an antigen of interest, wherein the mouse comprises a single human VH gene segment, a plurality of human DH gene segments and a plurality of JH gene segments, at the endogenous immunoglobulin heavy chain locus.
