ClotFoam is a surgical sealant and hemostatic agent designed to be used in cases of non-compressible hemorrhage for moderate to severe bleeding. It can be applied in the operating room through laparoscopic ports, or directly over lacerated tissue in laparotomy procedures or outside the operating room through a mixing needle and/or a spray injection method following abdominal, chest, extremities or other intracavitary sever trauma or surgery as a primary treatment or adjunct to hemostasis. Its crosslinking technology generates an adhesive three-dimensional polymeric network or scaffold that carries a fibrin sealant required for hemostasis. When mixed, Clotfoam produces a foam that spreads throughout the body cavity reaching the lacerated tissue to seal tissue and promote the coagulation cascade. The invention uses fibrin monomer polymerized by a change of pH as active sealing component.