The Research Foundation of State University of New York
发明人:
Chen, Wen-Tien
申请号：
AU2011201368
公开号：
AU2011201368B2
申请日:
2011.03.24
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2011201368B220130815.pdf#####P OPEku iM The Res:rc, Founditno of Stitc l 922 Amndd PIVCS -It SPA -I .'N'4 ABSTRACT The present invention relates to novel methods for detection and isolation of cancer cells with metastatic potential from blood, ascites and tumor tissue derived from subjects with metastatic cancer. The invention further relates to novel compositions for use as celladhesion matrices for detection and isolation of cancer cells and for use as blood filters by subjects having metastatic cancers. The methods and compositions of the invention may also be used in assays designed for measuring the metastatic potential of isolated cancer cells and for identification of agents having anti-metastatic potential. In addition, the invention relates to inhibiting the metastatic potential of cancer cells by modulating the activity of serine integral membrane proteases expressed on the surface of metastasizing cancer cells.
