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Composition comprising hydrophilized sulfasalazine and hyaluronic acid for the treatment of osteoarthritis and method for producing the same
专利权人:
ビーエムアイ コリア カンパニー リミテッド
发明人:
キム,スファン,ミン,キョンウ,ペク,ヨンジュン,イ,ソンヒ,ウ,ク,キム,ミンキョン
申请号:
JP2018532096
公开号:
JP6595717B2
申请日:
2016.12.16
申请国别(地区):
JP
年份:
2019
代理人:
摘要:
The present invention relates to a composition for treating osteoarthritis and a method for preparing the same, and more specifically, relates to a composition comprising hydrophilized sulfasalazine as an active ingredient and hyaluronic acid so as to enable effective treatment of osteoarthritis such as degenerative osteoarthritis by preventing joint wear in addition to symptom relief through intraarticular or local administration, and a method for preparing the same. When such a composition for osteoarthritis treatment is prepared by the preparation method according to the present invention, the dissolved state is maintained beyond a neutralization step after dissolution, preventing precipitation of sulfalazine by salting out occurring after neutralization , and thus a composition comprising high concentration of sulfasalazine can be prepared, and the composition prepared accordingly is highly effective in treating osteoarthritis, particularly degenerative osteoarthritis, through the intraarticular or local administration, since it comprises high concentration of sulfasalazine which had to be formulated at low concentration by conventional method due to poor solubility.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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