BIOGEN IDEC MA INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人:
申请号：
EP03755325.2
公开号：
EP1490110B1
申请日:
2003.03.13
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
A monoclonal antibody or an antigen binding fragment thereof that (a) specifically binds to ±v²6 but does not bind other av integrins； and (b) does not inhibit the binding of ²6 to latency associated peptide (LAP) with an IC50 value lower than that of 10D5. Said monoclonal antibody, wherein the antibody comprises a) the same heavy and light chain polypeptide sequences as an antibody produced by hybridoma 6. 2A1 (ATCC accession number PTA-3896) or b) the same heavy and light chain polypeptide sequences as an antibody produced by hybridoma 6.2E5 (ATCC accession number PTA-3897). The disclosure also relates to uses of same and to compositions comprising same.L'invention concerne des anticorps monoclonaux se liant de manière spécifique à αVβ6. L'invention concerne également des procédés d'utilisation de ces anticorps dans le traitement de mammifères atteints ou présentant un risque de contracter des maladies induites par αVβ6, ou dans le diagnostic de maladies induites par αVβ6.
