Aqueous Pharmaceutical formulation comprising 200 - 1000 U / ml [equimolar 200 - 1000 IU of insulin human] insulin glargine, with the condition that is not 684 U / ml insulin glargine; and its use to treat diabetes mellitus (Type I and II; an article of manufacture.FORMULACION FARMACEUTICA ACUOSA QUE COMPRENDE 200-1000 U/Ml [EQUIMOLAR A 200-1000 UI DE INSULINA HUMANA] DE INSULINA GLARGINA, CON LA CONDICION QUE NO SEA 684 U/Ml DE INSULINA GLARGINA; Y SU USO PARAR TRATAR LA DIABETES MELLITUS TIPO I Y II; UN ARTICULO DE FABRICACION.