SHONE CLIFFORD,ROBERTS APRIL,AHERN HELEN,MAYNARD SMITH Michael,LANDON JOHN
申请号：
IN720/MUMNP/2013
公开号：
IN2013MN00720A
申请日:
2013.04.12
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The present invention relates to recombinant antigens based on a fusion protein that consists of or comprises a first amino acid sequence and a second amino acid sequence wherein: a) the first amino acid sequence is provided by an amino acid sequence that has at least 80% sequence identity with an amino acid sequence consisting of residues 500 1850 of a A sequence or residues 1500 1851 of a Toxin B sequence and b) the second amino acid sequence is provided by an amino acid sequence that has at least 80% sequence identity with an amino acid sequence consisting of a long repeat unit located within amino acid residues 1851 2710 of a A sequence or within amino acid residues 1852 2366 of a B sequence though with the proviso that the fusion protein is not a polypeptide comprising amino acid residues 543 2710 of a A and with the proviso that the fusion protein is not a polypeptide comprising amino acid residues 543 2366 of a B. Also provided is the use of said antigens for the prevention/ treatment/ suppression of Clostridium difficile infection (CDI) together with methods for generating said antigens methods for generating antibodies that bind to said antigens and the use of said antibodies for the prevention/ treatment/ suppression of CDI.
