ARUMUGHAM, RASAPPA G.,PRASAD, A. KRISHNA,HAGEN, MICHAEL
申请号：
ES11151428
公开号：
ES2474173T3
申请日:
2004.12.17
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A peptide / protein / polypeptide immunogen conjugate having the formula: ** Formula ** where C is a CRM197 / polypeptide protein transporter, Xd is a functional group derivatized from an amino acid residue of the protein / polypeptide transporter, P it is a peptide immunogen molecule of an Aβ fragment covalently linked to the functional group derivatized from the amino acid residue of the protein / polypeptide transporter, where the Aβ fragment is selected from the group consisting of residues: 1-3, 1-4, 1 -5, 1-6, 1-7, 1-9, 1-10, 1-11, 1-12, 1-16, 1-28, 3-6, 3-7, 13-28, 15-24 , 16-22, 16-23, 17-23, 17-24, 18-24, 18-25, 17-28, 25-35, 33-42, 35-40 and 35-42 of Aß (SEQ ID NO : 21), R is a restriction molecule covalently bound to its functional group derivatized from an amino acid residue of the protein / polypeptide transporter, thus retaining the functionality of the transporter in such a way that retains its ability to or to obtain the desired immune responses against the peptide immunogen that would otherwise be given without a transporter, n is an integer greater than 0, but less than or equal to 85, and p is an integer greater than 0, but less than 85.Un conjugado inmunógeno peptídico/transportador de proteína/polipéptido que tiene la fórmula:**Fórmula** donde C es un transportador de proteína CRM197/polipétpido, Xd es un grupo funcional derivatizado de un residuo de aminoácido del transportador de proteína/polipéptido, P es una molécula de inmunógeno peptídico de un fragmento de Aß covalentemente unida al grupo funcional derivatizado del residuo de aminoácido del transportador de proteína/polipéptido, donde el fragmento de Aß se selecciona del grupo consistente en residuos: 1-3, 1-4, 1-5, 1-6, 1-7, 1-9, 1-10, 1-11, 1-12, 1-16, 1-28, 3-6, 3-7, 13- 28, 15-24, 16-22, 16-23, 17-23, 17-24, 18-24, 18-25, 17-28, 25-35, 33-42, 35-40 y 35-42 de Aß (SEQ ID NO: 21), R es una molécula de restricción covalentemente unida a su grupo funcional derivatizado de un residuo de am
