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МАТЕРИАЛЫ ДЛЯ ОФТАЛЬМОЛОГИЧЕСКИХ И ОТОРИНОЛАРИНГОЛОГИЧЕСКИХ УСТРОЙСТВ, СОДЕРЖАЩИЕ МНОГОБЛОЧНЫЙ ПЭГ МАКРОМЕР
专利权人:
НОВАРТИС АГ (CH)
发明人:
ЛАРЕДО Уолтер Р. (US)
申请号:
RU2014137150
公开号:
RU2014137150A
申请日:
2012.02.15
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. Polymeric materials for ophthalmic and otorhinolaryngological device soderzhaschiea) from 75 to 97% (w / w) of a monofunctional acrylate or methacrylate monomer of formula [1]:.. Where B = O (CH), NH (CH), or NCH ( CH) R = H, CH, CHCH, or CHOH n = 0-12 A = CHili O (CH) CH, wherein CHgruppa further substituted with - (CH) H, -O (CH) H, -CH (CH ), -CH, -OCH, -CHCH, F, Cl, Br, or I and m = 0-22 b) a difunctional acrylate or methacrylate polyfunctional monomer of formula [2]: wherein R, independently = H, CH, CHCH, or CHOH W, W independently = O (CH), NH (CH), NCH (CH), O (CH) CH, O (CHCHO) CH, O (CHCHCHO) CH, O (CHCHCHCHO) CH, or absent J = (CH), O (CHCHO) O, or is absent, provided that if W and W are absent, and J is absent d = 0-12 a = 1-12 and b = 1-24 and c) from 1 to 8% (wt / wt) branched polyethylene glycol macromer of formula [3]:.. [3] where k = 2-75 s = 0 or 1 t = 0-4 s and t can not both be equal to 0 Y independently = H, C (O) CCHR, CHCHNH, CHCHNHC (O) CCHR, CHCHCH (OH) CHOC (O) CCHR, CHCHNHC (O) NHCHCHOC (O) CCHR, C (O) NHCHCHOC (O) CCHR, or CHCHSH and r = H, CH, CHCH, or CHOH.2. The polymeric material for the device according to claim 1, wherein: B = O (CH) R = H or CH n = 1-4. iA = CH.3. The polymeric material of Claim apparatus 1, characterized in that:. R, independently = H or CH W, W independently = O (CH), O (CH) CH, or absent J = O (CHCHO) or absent provided that if W and W are absent toJ also absent d = 0-6 and b = 1-10.4. The polymeric material for the device according to claim 1, characterized in that:. K = 8-55 s = 0 or 1 t = 0 or 4 Y independently = H, C (O) CCHR, CHCHNH, CHCHNHC (O) CCHR or C (O) NHCHCHOC (O) CCHR and r = H, CH, CHCH, or CHOH.5. The polymeric device material of claim 4, characterized in that:. K = 11-35 s = 1 t = 0 Y = H, C (O) CCHR, CHCHNH, or CHCHNHC (O) CCHR and r = H or CH.6. The polymeric material for the device according to claim 1, characterized in that the monomer of formula [1] is selected from the group consisting
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