INSTITUTO DE TECNOLOGIA E PESQUISA;UNIVERSIDADE TIRADENTES
发明人:
ANA VERUSKA CRUZ DA SILVA MUNIZ,ANDRIELE MENDONÇA BARBOSA,CARLA COSTA,CLÁUDIO DARIVA,ELTON FRANCESCHI,FRANCINE FERREIRA PADILHA,JOÃO PAULO TEIXEIRA,KLEBSON SILVA SANTOS,MARIA BEATRIZ PRIOR PINTO OLIVE
申请号：
BR102017024898
公开号：
BR102017024898A2
申请日:
2017.11.21
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
product derived from azadirachta indica leaves with antiproliferative effect against human lymphoblastic cells. The present patent (pi) relates to a product having antiproliferative effects obtained from oil and / or extract derived from a single mass of azadirachta indica leaves, popularly known as neem. Said neem leaf derived product has high potential for pharmacological and medicinal application due to its photochemical characteristics as well as the activity to reduce the viability of properly proven human lymphoblastic B cells. More specifically, this invention discloses the details of obtaining the anti-proliferative, apoptosis-inducing, and malignant cell cycle blocking product, being able to prevent the growth / accumulation of human lymphoblastic cells (tk6). It has direct application in the pharmaceutical, cosmetic, human and veterinary medicine, food and beverage, nutrition and biotechnology industries. The product developed in this inventive patent falls within the scope of natural products with industrial potential pharmacological and medicinal effects, which can be applied as active component in different pharmaceutical, food and cosmetic formulations, for example.produto derivado das folhas de azadirachta indica com efeito antiproliferativo contra as células linfoblásticas humanas. a presente patente de invenção (pi) diz respeito a um produto com efeitos antiproliferativos obtido a partir de óleo e/ou extrato derivados de uma única massa das folhas de azadirachta indica, conhecida popularmente como nim. o dito produto derivado das folhas de nim possui elevado potencial de aplicação farmacológico e medicinal, devido as suas características fotoquímicas, bem como, a atividade para reduzir a viabilidade de células b linfoblásticas humanas devidamente comprovada. mais especificamente esta invenção revela os detalhes da obtenção do produto antiproliferativo, indutor de apoptose e bloqueador de ciclo celular maligno, sendo capaz de impedir o crescimento/ac
