Compounds of isoaromatic pyrethroids, a mixture with excellent thyroid hormone inhibitory activity； including the pharmaceutical components of these compounds； used in the treatment of allergic nephritis, asthma, atomic dermatitis, systemic lupus erythematosus, rheumatoid arthritis Oriasis, EPOC, etc.
ARIKAWA YASUYOSHI,JONES BENJAMIN,LAM BETTY,NIE ZHE,SMITH CHRISTOPHER,TAKAHASHI MASASHI,DONG QING,FEHER VICTORIA
申请号：
CL2012001745
公开号：
CL2012001745A1
申请日:
2012.06.25
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein G, L 1 , L 2 , R 1 , R 2 , R 3 , and R 4 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula I, pharmaceutical compositions containing them, and their use for treating disorders, diseases, and conditions involving the immune system and inflammation, including rheumatoid arthritis, hematological malignancies, epithelial cancers (i.e., carcinomas), and other disorders, diseases, and conditions for which inhibition of SYK is indicated.Compuestos derivados de pirrolidinonas heteroaromáticas fusionadas con actividad inhibitoria de tirosina quinasa esplénica； composición farmacéutica que los comprende； uso en el tratamiento de la rinitis alérgica, asma, dermatitis atópica, lupus eritematoso sistémico, artritis reumatoide, psoriasis, EPOC, entre otras
