PIETER SMID,WOUTER, 1 IWEMA BAKKER,HEIN COOLEN,LEONARDUS, A.J.M. SLIEDREGT,MARIA J.P. VAN DONGEN,JACOBUS, A.J. DEN HARTOG
申请号：
DO2013000009
公开号：
DOP2013000009A
申请日:
2013.01.09
申请国别(地区):
DO
年份:
2013
代理人:
摘要：
The present Invention relates to a FUSED Heterocyclic Derivative of the formula (i) wherein R1 is selected alquenilo Ciano, (C 2 - 4), alquinilo (C 2), alkyl ((1 - 4), each cn or optionally substituted with one or more Fluorine ATOMS, cycloalkyl (C 3 - 6 (c), cicloalquenilo 4 - 6) or a bicyclic (Group c, 8 - 10)Each optionally replaced with Halogen or alkyl ((1 - 4) optionally substituted with one or more Fluorine ATOMS, biphenyl, phenyl, naphthyl, each optionally substituted with one or more selected regardless of halogen substituents (alkyl, cyano, C 1 - 4) optionally Substituted with one or more Fluorine ATOMS,(C 1 - 4) alkoxy optionally substituted with one or more Fluorine ATOMS, amino, dimethylamino, cycloalkyl (3 - 6 and c) optionally substituted phenyl can be substituted with alkyl ((1 - 4) or Halogen substituted benzyl and phenyl, phenoxy, Benzyloxy, feniletilo or monocyclic heterocycle Optionally, each substituted with alkyl ((1 - 4)Z is a Liaison Group (- W - C - T - alquileno) where W adheres to R1 and select a Link, - O -, co -, - S -, - So - So -, -, - NH -, - ch = CH -, - C (Cf3 CEC = CH -) - CH2 -, -, -, - or - CO, co or co -, - NH - NH -, co - and trans ciclopropileno； nesunenterodeoalo adheres to the Group； and T / functional polysulfur Piri Say it and select a Link, - O -, - S -, - So - So -, -, - NH -, co -, - C = C -, - CEC,And transciclopropileno； R2 is H or one or more selected regardless of cyano substituents, halogen, alkyl ((1 - 4) optionally substituted with one or more Atoms of halogen, alkoxy or (C 1 - 4) optionally substituted with one or more Halogen Atoms； The structure of the ring. Containing a nitrogen Atom； X is selected from c or N； if X is CR3 is selected from H and alkyl ((1 - 4), another form of R3 is not present； and select or NH, Q and S； The structure is a cyclic Amine of 5, 6 or 7 members； and R4 is alquileno (C 1 - 4 - R5) where one or more carbon Atoms in The Group can be replaced independently with alquileno One or more
