您的位置: 首页 > 农业专利 > 详情页

METHOD FOR PRODUCING ZINC INSULIN COMPLEXES
专利权人:
НОВО НОРДИСК А/С
发明人:
АНДЕРСЕН Лене,ХАНСЕН Роза Ребекка Эрритсёэ,ЙЕППЕСЕН Пер
申请号:
RU2012148821
公开号:
RU2012148821A
申请日:
2011.05.09
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of obtaining a pharmaceutical finished dosage form containing an insulin derivative, the method comprising dissolving the insulin derivative in water, adjusting the pH of the solution to a value above pH 7.2, adding a zinc-containing solution with constant stirring, and adjusting the pH to the target pH of the finished medicinal product forms, and wherein the insulin derivative contains an insulin molecule in which there is a side chain attached to the ε-amino group of the Lys residue present in the B-chain of human insulin or an analogue thereof, the side chain has the general formula: -WXYZ, where W is: an α-amino acid residue containing a carboxyl group in the side chain, while this residue forms, with the participation of one of its carboxyl groups, an amido group with the ε-amino group of the Lys residue present in the B-chain of the starting insulin; a chain consisting of two, three or four α-amino acid residues linked together through urea bonds, while this chain - through an amide bond - is connected to the ε-amino group of the Lys residue present in the B-chain of the starting insulin when this, amino acid residues in W are selected from the group of amino acid residues having a neutral side chain and amino acid residues having a carboxyl group in the side chain, such that W contains at least one amino acid residue that has a carboxyl group in the side chain; an icovalent bond from X to the ε-amino group of the Lys residue present in the B chain of the starting insulin; X is: —O -; - CH (COOH) O -; - CO-N (COOH) CHO -; - CO-N (CHCOOH ) CHCON (CHCOOH) CHO -; - CO-N (UNSUPS) SCHS -; - CO-N (UNSUPS) CHCHCON (UNSU) SCHS -; - CO-NHCH (COOH) (CH) N1. Способ получения фармацевтической готовой лекарственной формы, содержащей производное инсулина, при этом способ включает растворение производного инсулина в воде, подведение рН раствора до значения выше рН 7,2, добавление содержащего цинк раствора при постоянном перемешивании и подведение рН до целевого з
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充