The present invention relates to: a pharmaceutical composition for preventing or treating oral diseases and a health functional food for improving health, a preservative composition, and a whitening pharmaceutical composition and cosmetic composition, which include (stipitalide, 5,8-dihydroxy-1H-cyclohepta-[c]furan-1,6(3H)-dione) as an effective ingredient. The composition including stipitalide has low toxicity, has good antibacterial activity against various bacteria, can be usefully employed in various oral products and foods, and as preservatives for cosmetics or medicines, and has good inhibitory activity for melanin synthesis so as to be capable of being usefully employed even in whitening-related products.Linvention concerne une composition pharmaceutique de prévention ou de traitement daffections buccales, et un aliment naturel fonctionnel pour améliorer la santé. Elle concerne une composition de conservation, une composition pharmaceutique de blanchiment et une composition cosmétique, qui comprennent (stipitalide,5,8-dihydroxy-1H-cyclohepta[c]furane-1,6(3H)-dione) comme ingrédient actif. La composition comprenant stipitalide présente une faible toxicité et une bonne activité antibactérienne contre diverses formes de bactéries. Elle peut être utilisée dans divers aliments et produits destinés à la voie orale, et comme agents de conservation de produits cosmétiques ou de produits médicaux, et présente une bonne activité inhibitrice de la synthèse de la mélanine, de sorte quelle peut semployer utilement même dans des produits de blanchiment.본 발명은 스티피탈리드(stipitalide, 5,8-dihydroxy-1H-cyclohepta-[c]furan-1,6(3H)-dione)를 유효성분으로 함유하는 구강질환 예방 또는 치료용 약학 조성물 및 개선용 건강기능식품, 방부제 조성물, 미백용 약학 조성물 및 화장료 조성물에 대한 것이다. 상기 스티피탈리드를 포함하는 조성물은 독성이 낮고 다양한 세균에 대한 항균력이 우수하여 구강관련 다양한 제품과 식품, 화장품 또는 의약품의 방부제로 유용하게 사용될 수 있으며, 또한 멜라닌 합성에 대한 저해활성이 우수하여 미백 관련 제품으로도 유용하게 사용될 수 있다.
