In embodiments of person-centric RFID tag activation, an RFID tag is configured so as to be active or inactive based on proximity to a person. An RFID tag includes an integrated circuit (IC), an antenna coupled to the IC, and skin proximity activation circuitry. For example embodiments, the skin proximity activation circuitry is configured to establish an active state for the RFID tag if proximate to skin and an inactive state if not proximate to skin. For an example implementation, an RFID tag is placed in an operationally active state in which an interrogation signal is detectable by an IC if at least one skin contact point is touching skin. For another example implementation, an RFID tag is placed in a communicatively active state in which a received interrogation signal may trigger the sending of a response signal if a detected temperature comports with a human-appropriate range of temperatures.