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Pharmaceutical formulation of apomorphine for buccal administration
专利权人:
Amarin Pharmaceuticals Ireland Limited
发明人:
Anthony Clarke
申请号:
US13669148
公开号:
US08772309B2
申请日:
2012.11.05
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention provides a kit comprising, in separate compartments of a container, the following components (a) and (b): (a) a combination of apomorphine or a pharmaceutically acceptable acid addition salt thereof and a pharmaceutically acceptable excipient or carrier; and (b) a solution which comprises a diluent and a pH modifying agent; the components being presented such that they can be combined at the point of use into a formulation which is adjusted to a pH ranging from mildly acidic to alkaline and which is suitable for buccal administration. The formulation is useful in treating Parkinson's disease and in promoting sexual function.
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