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Fusion proteins of HIV regulatory/accessory proteins
专利权人:
Paul Howley
发明人:
Paul Howley,Sonja Leyrer,Eva Felder
申请号:
US12611188
公开号:
US08137931B2
申请日:
2009.11.03
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or derivatives of the amino acid sequence of one or more of said proteins, wherein the fusion protein is not processed to individual HIV proteins having the natural N and C termini. The invention further concerns nucleic acids encoding said proteins, vectors comprising said nucleic acids, and methods for producing said proteins. The fusion protein, nucleic acids and vectors are usable as vaccines for the at least partial prophylaxis against HIV infections.
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