PLS-Design GmbH;Klinikum rechts der Isar der Technischen Universität München;Helmholtz Zentrum München Forschungszentrum für Gesundheit und Umwelt GmbH
发明人:
申请号：
EP13075040.9
公开号：
EP2813242A1
申请日:
2013.06.13
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
The invention relates to a pharmaceutical composition for local modulation of T cell and B cell responses at the site of allergen or antigen presentation, made of one or more preparations comprising one or more antigens or allergens, and a therapeutically effective dose of two or more low molecular weight immune modulators selected from four groups of tolerance-inducing therapeutics comprising inhibitors of complement-mediated functions, inhibitors of tumor necrosis factor receptor 1 (TNFR1)-mediated functions, inhibitors of interleukin 4- and interleukin 13-mediated functions', and therapeutic agents suitable for vitamin D3 supplementation wherein preferably two or more low molecular weight immune modulators and one or more antigens or allergens are coated or adsorbed on or embedded in a matrix, wherein the matrix is selected as to enable sustained release of one or more antigens or allergens and two or more immune modulators for the treatment of T cell-mediated diseases, including allergy, allergic asthma, and autoimmune disease such as type 1 diabetes, rheumatoid arthritis, multiple sclerosis.
