[Problem to be Solved] To provide a hollow fiber membrane for blood treatment that can be used in a blood purifier having a high solute permeability enabling a certain amount of albumin leakage to be achieved in the blood treatment, where a time-dependent change in albumin leakage can be reduced over the entire period of the blood treatment, and a method for producing the same. [Solution] A polysulfone hollow fiber membrane for blood treatment, comprising a polysulfone resin, a hydrophilic polymer, and a fat-soluble substance, wherein the amount of the fat-soluble substance present in the surface of the membrane is 10 to 300 mg per square meter； the content of the fat-soluble substance present in the surface of the membrane is 40 to 95% by mass when the content of the fat-soluble substance present in the entire membrane is assumed as 100% by mass； and the clearance rate of ²2MG converted to that for 1.5 m 2 for a blood purifier assembled using the membrane is 65 mL/min or more.
