Measuring degree of polymerisation for capsular saccharides that contain sialic acid

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专利权人:

Novartis Vaccines and Diagnostics SRL

发明人:

Bardotti, Angela

申请号：

AU2005245689

公开号：

AU2005245689B2

申请日:

2005.05.23

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

The degree of polymerisation (DP) is an important parameter for analysis of saccharideantigens, particularly in glycoconjugates. The invention provides methodsthat can be used to measure DP for capsular saccharides, particularly for meningococcalsaccharides . from serogroups W135 and Y. A preferred method is basedon reduction of terminal sialic acid residues on saccharides, with DP then beingcalculated by comparing the molar ratio of total sialic acid to reduced sialicacid.

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