PROBLEM TO BE SOLVED: To provide an HIV-1 reverse transcriptase activity inhibitor.SOLUTION: Disclosed is 1. an HIV-1 reverse transcriptase activity inhibitor containing Brasenia schreberi Gmel. extract as an active ingredient 2. the HIV-1 reverse transcriptase activity inhibitor in which Brasenia schreberi Gmel. extract contains at least one kind of gossypetin and hypolaetin 7-O-glucoside and 3. the HIV-1 reverse transcriptase activity inhibitor containing derivatives of substituents at position 2 (R2) and position 7 (R1) of gossypetin and hypolaetin 7-O-glucoside as active ingredients. (R1 and R2 are respectively at least one kind selected from H, OH, and OR R is at least one kind of alkyl or glucosyl group selected from carbon number 1-3)COPYRIGHT: (C)2016,JPO&INPIT【課題】HIV-1逆転写酵素活性の阻害剤の提供。【解決手段】1.ジュンサイ抽出物を有効成分とするHIV-1逆転写酵素活性の阻害剤。2.ジュンサイ抽出物はgossypetin、及びhypolaetin 7-O-glucosideの少なくとも1種を含有するHIV-1逆転写酵素活性の阻害剤。3.gossypetin、及びhypolaetin 7-O-glucosideの2位置換基(R1)と7位置換基(R2)の誘導体を有効成分とするHIV-1逆転写酵素活性の阻害剤。(R1及びR2は各々、H、OH、ORから選ばれる少なくとも1種;Rは炭素数1~3から選ばれる少なくとも1種のアルキル基、或いはグルコシル基)【選択図】なし
