A solid oral pharmaceutical composition in the form of tablets comprising: - a first solid oral pharmaceutical formulation in the form of at least one micro-tablet, the micro-tablet consisting of a core comprising at least one Krebs cycle precursor salt as active ingredient, and of a coating comprising at least one coating agent, and - a second oral pharmaceutical formulation in the form of at least one mini-tablet, the mini-tablet consisting of a core comprising at least one bicarbonate salt as active ingredient and at least one prolonged-release matrix, and of a coating comprising at least one coating agent. The use thereof as a medicament, in particular in the treatment and/or prevention of cystinuria.
