A system and method that facilitates minimally invasive spine surgery. The system includes screw preparation instruments that include a targeted guide with a laser attached to a fluoroscope, at least one polyaxial screw and rod guidance instruments that selectively insert the at least one polyaxial screw within the spine. The screw preparation instruments include an awl, a hand-held drill or tap, a ball-tipped probe, a cannulated depth gauge ruler, and a hexagonal screwdriver. Each screw preparation instrument have respective handles marked with a targeting guide oriented along respective central axes of the instruments. The rod guidance instruments include a rod with a tapered tip, a T-handle rod holder, a T-handle alignment guide, an alignment marker sleeve, a flexible alignment marker with a polyaxial head, and a template rod.
