The present invention relates to a lettuce plant resistant to Bremia lactucae races B1:1, B1:4, B1:5, B1:6, B1:7, B1:10, B1:12, B1:13, B1:14, B1:15, B1:16, B1:17, B1:18, B1:21, B1:22, B1:23, B1:24, and B1:25, which plant comprises a genetic determinant which causes the resistance and which genetic determinant is obtainable by introgression from a plant grown from seeds of which a representative sample was deposited under accession number NCIMB 41761, and wherein the said genetic determinant in the seeds of seed deposit number NCIMB 41761 is at least linked to marker SCM05 with SEQ ID NO:4, marker LR0029 with SEQ ID NO:5, and marker LK0036 with SEQ ID NO:6, and optionally also to one or more of the markers selected from the group consisting of marker SCW09 with SEQ ID NO:1, marker CL922 with SEQ ID NO:2, marker SCV12 with SEQ ID NO:3, marker LR0096 with SEQ ID NO:7, and marker SCI11 with SEQ ID NO:8. Preferably, the genetic determinant comprises genes Dm3, Dm6 and R18 in coupling phase.
