Gregory Lawrence VERDINE,Brian Roger BOWMAN,Mathew Edward SOWA,Joshua Alan Van Dyke BLODGETT,Keith Earl ROBISON,Dylan Talbot STILES,Jay Paul MORGENSTERN,Sharon Ann TOWNSON,Uddhav Kumar SHIGDEL
申请号：
US15542350
公开号：
US20180273544A1
申请日:
2016.01.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein such as CEP250. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of the target protein. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of target protein activity.
