Method of preparing an alkylated salicylamide of formula from a protected and activated salicylamide that is protected to prevent the reaction of the hydroxyl moiety and is activated in the nitrogen atom of the amide group, the method comprising the steps of: (a) renting a salicylamide protected and activated having the formula in the nitrogen atom of the amide group with a dicarboxylate alkylating agent of formula to form a protected and activated dicarboxylated salicylamide of formula ** Formula ** in which R1, R2, R3 and R4 are independently hydrogen； halogen； C1-C4 alkoxy, optionally substituted with -OH or F； -OH； C1-C4 alkyl, optionally substituted with -OH or F； -COOH； -OC (O) CH3； -SO3H； nitrile； o-NR9R10； R5 is a protecting group； R6 is an activating group； R5 and R8 combine to form a substituted or unsubstituted cyclic group； R7 is a linear or branched C1-C20 alkylene； R7 is optionally substituted with C1-C4 alkyl, alkenyl with up to 4 carbon atoms, oxygen, nitrogen, sulfur, halogen, -OH, C1-C4 alkoxy, aryl, heteroaryl or vinyl； R7 is optionally interrupted with aryl, heteroaryl, vinyl, oxygen, nitrogen or sulfur； R8 and R11 are independently C1-C4 alkyl or C1-C4 haloalkyl； R9 and R10 are independently hydrogen, C1-C4 alkyl or oxygen； R18 is hydrogen； R19 is -COOH or a salt thereof； X is a suitable leaving group； and (b) (i) deprotect, (ii) deactivate and (iii) decarboxylate the protected and activated dicarboxylated salicylamide to form the alkylated salicylamide.Método de preparación de una salicilamida alquilada de fórmulaa partir de una salicilamida protegida y activada que se protege para impedir la reacción del resto hidroxilo yse activa en el átomo de nitrógeno del grupo amida, comprendiendo el método las etapas de:(a) alquilar una salicilamida protegida y activada que tiene la fórmulaen el átomo de nitrógeno del grupo amida con un agente alquilante de dicarboxilato de fórmulapara formar una salicilamida dicarboxilada protegida y activada de fórmula
