Compounds derived from 1 - [4 - [6 - [[(2 - 5 - cloropirimidin - il) amino] methyl] - 2 - methyl - oxifenil pyrimidin-4-yl]] - metansulfonamida or its Salts as inhibitors of DGAT2; Process for their Preparation; Pharmaceutical composition that comprises; and its use for the treatment of cardiovascular disease, dis Lipidemia, atherosclerosis or hypertriglyceridemia.COMPUESTOS DERIVADOS DE 1-[4-[6-[[(5-CLOROPIRIMIDIN-2-IL)AMINO]METIL]-2-METIL-PIRIMIDIN-4-IL]OXIFENIL]-METANSULFONAMIDA O SUS SALES, COMO INHIBIDORES DE DGAT2; PROCESO PARA SU PREPARACION; COMPOSICION FARMACEUTICA QUE LOS COMPRENDE; Y SU USO PARA EL TRATAMIENTO DE UNA ENFERMEDAD CARDIOVASCULAR, DISLIPIDEMIA, ATEROSCLEROSIS O HIPERTRIGLICERIDEMIA.