Samuel C. Wagner,Thomas E. Ichim,Santosh Kesari,Amit N. Patel
申请号：
US15004864
公开号：
US20160213764A1
申请日:
2016.01.22
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Disclosed are composite cancer vaccines, in one embodiment generated through 3-dimensional bioprinting or through inoculation of roller cultures. The utilization of decellularized biological matrices such as placental tissue or subintestinal submucosal tissue is disclosed as a substrate for 3-dimensional tissue culture. In one embodiment tumor cells are assembled with monocytes and/or mesenchymal stem cells to represent in vivo existing tumors. The invention teaches means of generating off-the-shelf tumor vaccines containing antigenic properties similar to in vivo growing tumors, which cannot be currently replicated under existing 2-dimensional tumor culture means of generating cell lines
