COOKE, ANDREW JOHN,BENNETT, DAVID JONATHAN,EDWARDS, ANDREW STANLEY,ROUGHTON, ANDREW LAIRD,NEAGU, IRINA,CHAN, JUI-HSIANG,HO, KOC-KAN,ANSARI, NASRIN,MORRIS, MICHELLE LEE,RONG, YAJING,OHLMEYER, MICHAEL
申请号：
CA2733661
公开号：
CA2733661C
申请日:
2009.08.26
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to 1-(4-ureidobenzoyl)piperazine derivativeshaving the general Formula I (We bringto your attention that formula I is not provided on this electronic version asit is provided in the abstract of the paper copy) WhereinR1 is (C1-8)alkyl, (C3-8)cycloalkyl or (C1-3)cycloalkyl(C1-3)alkyl, each ofwhich may be substituted by hydroxy, cyano or halogen；R2 represents 1 or 2 optional halogens； R3 is (C1-6)alkyl, (C3-6)cycloalkyl or(C3-6)cycloalkyl(C1-3)alkyl, each of which may be substitutedby one or more halogens； A represents a heteroaryl ring system comprising 1-3heteroatoms selected from N, O and S,which ring system is 5-or 6-membered when X is C, and 5-membered when X is N；n is 1 or 2； or a pharmaceutically acceptablesalt thereof； to pharmaceutical compositions comprising the same, and to theuse of a these 1-(4-ureidobenzoyl)piperazine derivativesfor the manufacture of a medicament for treating or preventing atherosclerosisand related disorders associated with cholesteroland bile acids transport and metabolism.
