Humanized anti-HMGB1 antibody or antigen-binding fragment thereof

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专利权人:

株式会社イーベック;国立大学法人 岡山大学

发明人:

高田 賢蔵,寅嶋 崇,西堀 正洋

申请号：

JP2014558456

公开号：

JP6247646B2

申请日:

2013.12.06

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

The present invention provides a humanized anti-HMGB1 antibody which specifically binds to a sequence consisting of the C-terminal 8 amino acid residues (EEEDDDDE) of HMGB1 protein and is effective for treatment or prevention of various inflammatory diseases related to this protein, as well as an antigen-binding fragment thereof. The present invention also provides a pharmaceutical composition comprising such an antibody or antigen-binding fragment thereof.

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中国工程科技知识中心

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