IDENTIFICATION D'UN ÉPITOPE DE LYMPHOCYTE T DE PREVOTELLA COPRI QUI INDUIT DES RÉPONSES DE LYMPHOCYTE T CHEZ DES PATIENTS ATTEINTS DE POLYARTHRITE RHUMATOÏDE

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专利权人:

The General Hospital Corporation

发明人:

STEERE, Allen C.,DROUIN, Elise E.

申请号：

EP17810878

公开号：

EP3463441A4

申请日:

2017.06.06

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

Disclosed herein are methods of diagnosing Rheumatoid arthritis in a subject comprising determining whether the subject is immunologically reactive with P. copri or a portion thereof. In one aspect of the invention the immunological reactivity of the subject to one or more protein of P. copri or polypeptide fragments thereof such as protein Pc-p27 or polypeptide fragments thereof, as compared to an appropriate control, indicates the subject has rheumatoid arthritis. Examples of specific assays and kits for use with the methods are also disclosed.

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