Described are pressure-sensitive adhesive polymers (PSAs) useful, for example, for application to the skin, such as in the field of transdermal drug delivery. The PSAs include polar groups modeled on one or more polar portions of skin lipids, which contribute to good skin adhesion properties. Methods of making the PSAs, compositions comprising them, and methods of making and using them also are provided.本發明闡述壓力敏感性黏合劑聚合物(PSA),其可用於(例如)施加至皮膚,例如用於經皮藥物傳送之領域中。該等PSA包括模塑皮膚脂質之一或多個極性部分之極性基團,其有助於良好皮膚黏合性質。本發明亦提供製作該等PSA之方法、包含其之組合物及製作及使用該等組合物之方法。