Purdue Research Foundation;National Institutes of Health
发明人:
Mark S. Cushman,Daniel E. Beck,Yves Pommier
申请号：
US16081959
公开号：
US10759795B2
申请日:
2017.03.15
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention described herein pertains to four series of aza-A-ring indenoisoquinolines, which are inhibitors of topoisomerase IB (Top1), and the processes for preparing said aza-A-ring indenoisoquinolines. Also described are methods for treating cancer in mammals using the described aza-A-ring indenoisoquinoline compounds or pharmaceutical formulations thereof.
